Leptin, puberty and reproductive function: lessons from animal studies and observations in humans.
نویسندگان
چکیده
Wieland Kiess, Werner F Blum and Michel L Aubert Children’s Hospital, Department of General Paediatrics and Neonatology, University of Giessen, Feulgenstr. 12, D-35385 Giessen, Germany, Lilly Germany, Saalburgstr. 153, D-61350 Bad Homburg, Germany, and Division of Biology of Growth and Reproduction, Department of Paediatrics, School of Medicine, University of Geneva, CH-1211 Geneva 14, Switzerland
منابع مشابه
Leptin in reproduction.
PURPOSE OF REVIEW Leptin, a key hormone in energy homeostasis and neuroendocrine function, has a permissive role in initiating puberty and is crucial in the pathogenesis of reproductive dysfunction in several disease states of energy imbalance. KiSS1 neurons have recently been suggested to mediate leptin's effect on the reproductive system. New insights from recent animal studies and clinical t...
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BACKGROUND The functional reproductive alterations seen in women with type 1 diabetes (T1D) have changed as therapy has improved. Historically, patients with T1D and insufficient metabolic control exhibited a high prevalence of amenorrhea, hypogonadism and infertility. This paper reviews the impact of diabetes on the reproductive axis of female T1D patients treated with modern insulin therapy, ...
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A critical amount of energy reserve is necessary for puberty initiation, for normal sexual maturation and maintenance of cyclicity and fertility in females of most species. Therefore, the existence of circulating metabolic cues which directly modulate the hypothalamus-pituitary-gonad axis is predictable. The adipocyte-derived hormone leptin is one of these cues having been studied extensively i...
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insulin or leptin resistance, the repercussions may include both imbalanced metabolic homeostasis and reproductive dysfunction. Indeed, leptin-deficient patients become hyperphagic, massively obese, and infertile. This eBook has assembled multidisciplinary specialists to provide up-to-date information on recent advances in understanding the complex physiologic interaction between metabolism and...
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عنوان ژورنال:
- European journal of endocrinology
دوره 138 1 شماره
صفحات -
تاریخ انتشار 1998